Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Methicillin Resistant Staphylococcus aureus Strains Isolated from Patients in Intensive Care Units

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Macrolide-lincosamide-streptogramin B resistant phenotypes and genotypes for methicillin-resistant Staphylococcus aureus in Turkey, from 2003 to 2006.

Methicillin-resistant Staphylococcus aureus (MRSA) strains with inducible macrolide-lincosamide-streptogramin B (iMLS(B)) resistance phenotype may lead to clinical failure during clindamycin (CLI) therapy. The aim of this study was to determine the incidence of MLS(B) phenotypes by using D-test method and genotypes by using multiplex real-time PCR method in MRSA strains. A total of 265 MRSA str...

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Prevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in S. aureus Isolated from Patients in Tehran, Iran

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Novel locus required for expression of high-level macrolide-lincosamide-streptogramin B resistance in Staphylococcus aureus.

The yycF1(Ts) mutation in Staphylococcus aureus conferred hypersensitivity to macrolide-lincosamide-streptogramin B (MLS(B)) antibiotics on strains either containing or lacking ermB. The overexpression of the S. aureus Ssa protein restored the yycF1 mutant to wild-type levels of susceptibility. Inactivation of ssa in an unmutagenized strain dramatically reduced ermB-based resistance. Conditiona...

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ژورنال

عنوان ژورنال: Flora the Journal of Infectious Diseases and Clinical Microbiology

سال: 2017

ISSN: 1300-932X,2602-2842

DOI: 10.5578/flora.58638